Demos aren’t cutting it anymore—over the past two weeks vendors and labs moved AI from experiments into systems you can run. Here’s what you’ll get: concrete signals and dates showing the pivot to production. Replit open‐sourced an agentic coding environment on 2024‐12‐26; Databricks added “AI Tools” on 2024‐12‐27; Google and Meta published on‐device inference updates (12‐27 and 12‐30); Isomorphic Labs and Eli Lilly expanded collaboration on 12‐23 and a bioRxiv preprint (12‐28) showed closed‐loop AI‐driven wet labs; NIH and a JAMA study (late‐Dec 2024/12‐29) pushed workflow validation in healthcare; Nasdaq (12‐22) and BIS (12‐24) highlighted ML for surveillance; quantum roadmaps focus on logical qubits; platform teams and creative tools are integrating AI with observability and provenance. Bottom line: the leverage is in tracking how infrastructure, permissions, and observability reshape deployments and product risk.

Over 60% of developers now use AI tools — and in the last two weeks AI stopped being a novelty and started becoming infrastructure. Here’s what you need: who did what, when, and why it matters for your products and operations. Microsoft launched Phi‐4 (Phi‐4‐mini and Phi‐4‐multimodal) on 2024‐12‐18 for Azure and on‐device via ONNX/Windows AI Studio; Apple (2024‐12‐19) showed ways to run tens‐of‐billions‐parameter models on iPhones using flash and quantization; Meta updated Llama Guard 3 on 2024‐12‐20 for multimodal safety. Platform moves — GitHub Copilot Workspace (preview) 2024‐12‐16, Backstage adoption (12‐20), HashiCorp AI in Terraform (12‐19) — embed agents into developer stacks. Pharma deals (Absci/AZ 12‐17, Generate/Amgen 12‐19), market surveillance rollouts (Nasdaq, BIS), and quantum roadmaps all point to AI as core infrastructure. Short term: prioritize wiring models into your systems — data plumbing, evaluation, observability, and governance.

Struggling with trade-offs between speed, cost, and correctness? Here’s what you need from two weeks of product and research updates. OpenAI quietly listed o3 and o3‐mini on 2024‐12‐28, signaling a pricier, higher‐latency “reasoning” tier for coding and multi‐step planning. GitHub updated Copilot Workspace docs on 2024‐12‐26 and enterprises piloted task‐level agents into monorepos, pushing teams to build guardrails. Google (preprint 2024‐12‐23) and Quantinuum/Microsoft (updates in late Dec) shifted quantum KPIs to logical qubits with error rates ~10−3–10−4. BioRxiv posted a generative antibody preprint on 2024‐12‐22 and a firm disclosed Phase I progress on 2024‐12‐27. A health system white paper (2024‐12‐30) found 30–40% note‐time savings with 15–20% manual fixes. Expect budgets for premium reasoning tokens, staged Copilot rollouts with policy-as-code, and platform work to standardize vectors, models, and audits.

If your teams still treat AI as experiments, two weeks of industry moves (late Dec 2024) show that's no longer enough: vendors shifted from line‐level autocomplete to agentic, multi‐file coding pilots (Sourcegraph 12‐23; Continue.dev 12‐27; GitHub Copilot Workspace private preview announced 12‐20), Qualcomm, Apple patent filings, and Meta each published on‐device LLM roadmaps (12‐22–12‐26), and quantum, biotech, healthcare, fintech, and platform teams all emphasized production metrics and infrastructure over novel models. What you get: a clear signal that the frontier is operationalization—platformized LLM gateways, observability, governance, on‐device/cloud tradeoffs, logical‐qubit KPIs, and integrated drug‐discovery and clinical imaging pipelines (NHS: 100+ hospitals, 12‐23). Immediate next steps: treat AI as a shared service with controls and telemetry, pilot agentic workflows with human‐in‐the‐loop safety, and align architectures to on‐device constraints and regulatory paths.

If you still think AI is just autocomplete, wake up: in the two weeks from 2024-12-22 to 2025-01-04 major vendors moved AI into IDEs, repos, devices, labs and security frameworks. You’ll get what changed and what to do. JetBrains (release notes 2024-12-23) added multifile navigation, test generation and refactoring inside IntelliJ; GitHub rolled out Copilot Workspace and IDE integrations; Google and Microsoft refreshed enterprise integration patterns. Qualcomm and Nvidia updated on-device stacks (around 2024-12-22–12-23); Meta and community forks pushed sub‐3B LLaMA variants for edge use. Quantinuum reported 8 logical qubits (late 2024). DeepMind/Isomorphic and open-source projects packaged AlphaFold 3 into lab pipelines. CISA and OSS communities extended SBOM and supply‐chain guidance to models. Bottom line: AI’s now infrastructure—prioritize repo/CI/policy integration, model provenance, and end‐to‐end workflows if you want production value.

Worried about latency, privacy, or un‐auditable AI in your products? In the last two weeks vendors shifted multimodal and compiler work from “cloud‐only” to truly on‐device: Apple’s MLX added optimized kernels and commits (2024‐12‐28 to 2025‐01‐03) and independent llama.cpp benchmarks (2024‐12‐30) show a 7B model at ~20–30 tokens/s on M1/M2 at 4‐bit; Qualcomm’s Snapdragon 8 Gen 4 cites up to 45 TOPS (2024‐12‐17) and MediaTek’s Dimensity 9400 >60 TOPS (2024‐11‐18). At the same time GitHub (docs 2024‐12‐19; blog 2025‐01‐02) and JetBrains (2024‐12‐17, 2025‐01‐02) push plan–execute–verify agents with audit trails, while LangSmith (2024‐12‐22) and Arize Phoenix (commits through 2024‐12‐27) make LLM traces and evals first‐class. Practical takeaway: target hybrid architectures—local summarization/intent on-device, cloud for heavy retrieval—and bake in tests, traces, and governance now.

Worried AI is still just a research toy? Here’s a two‐week briefing so you know what to do next. Major vendors pushed AI into devices and workflows: Apple (Dec 16) rolled out on‐device models in iOS 18.2 betas, Google tightened Gemini into Android and Workspace (Dec 18–20), and OpenAI tuned GPT‐4o mini and tool calls for low‐latency apps (Dec). Teams are building agentic SDLCs—PDCVR loops surfaced on Reddit (Jan 3) and GitHub reports AI suggestions accepted in over 30% of edits on some repos. In biotech, AI‐designed drugs hit Phase II (Insilico, Dec 19) and Exscientia cited faster cycles (Dec 17); in vivo editing groups set 2026 human data targets. Payments and markets saw FedNow adoption by hundreds of banks (Dec 23) and exchanges pushing low‐latency feeds. Immediate implications: adopt hybrid on‐device/cloud models, formalize agent guardrails, update procurement for memory‐safe tech, and prioritize reliability for real‐time rails.